NEW: The First Safe And Effective Retinoic Acid Ester Serum You Don’t Need A Prescription For

Retanoic Acid Serum

Under normal conditions, retinoic acid (a retinoid or product of vitamin A) is a prescription drug. No one would dream of letting you use it without a doctor’s supervision, let alone at a concentration of 3% – the max most doctors would ever dream of using is usually around 0.1%. So, what if we told you that Lamelle Research Laboratories has just launched the first non-prescription retinoic acid serum at 3% that you can safely use at home (following your therapist’s instructions, of course)?

You’re going to want to remember the name: Lamelle Correctives 3.0 RA Serum, a new member of Lamelle’s Correctives range of serums.

But first: what is retinoic acid and why do you need it for your skin? Well, it’s kind of been an elusive secret to anti-ageing for some time now.



Scientists have known for a while that retinoic acid (RA) does some really amazing things for your skin: from powerfully cleaning elastosis and keratosis to boosting your collagen production, skin thickness and texture, not to mention offering potent skin protection. The problem is that it was always just a little too potent to apply topically.

Before Lamelle Correctives 3.0 RA Serum, the only way to get the skin benefits of retinoic acid without a prescription was to opt for less effective products containing retinol (vitamin A). Retinol is commonly found in products today, including some types of chemical skin peels, like those that help fix hyperpigmentation. Basic retinol is a little safer to use but the effects are diluted. That’s because RA is just a small part of retinol. See, retinol is broken down into various parts (called retinoids) inside the body, each one doing something different in the body.

The one retinoid that does all the amazing things for your skin is retinoic acid (more on everything it does later). So, naturally, we tried isolating RA to just give those targeted skin benefits. Problem was, it’s a little too potent to apply just like that.

Putting straight up RA on your skin causes adverse side effects like itching, redness, burning and peeling. So much so, that RA was classified as a drug, which you need a prescription to get. So, we’ve had to settle for using the less effective retinol. Until now.



Lamelle Research Laboratories took a closer look at the structure of RA molecules and how they work inside your skin, and noticed something very important. RA is absorbed by cells through a series of retinoic acid receptors (RARs), but only a few specific RARs trigger the adverse side effects we associate with RA.

So, Lamelle helped realise an all-new, stable and tolerable form of RA, an ester of all-trans retinoic acid, that’s specifically designed to bypass all the RARs that trigger the bad effects and only impact those RARs that give the desired results.

This new form of retinoic acid serum is safe, effective and gives all the skin-health benefits of RA without the negative side effects. Lamelle’s unique new form of RA has proven to be so tolerable that Lamelle can supply it in higher concentrations than anyone else would ever dream of delivering RA in. (Doctors today will seldom even try to use retinoic acid above 0.1% concentration, while Lamelle can supply it in 3% or even as high as 5%, safely.)



Anti-ageing Serum

Find Lamelle’s advanced new form of RA in Correctives 3.0 RA Serum. A few drops of this non-prescription ester of all-trans retinoic acid in a clear serum form applied to clean and dry skin at night – after water-based serums but before moisturiser – provides better results in treating the signs of ageing than nearly all other forms of non-prescription retinoid.



Epidermal benefits:

  1. Exfoliates and smoothens
    Inhibits the proteins that hold corneocytes (cells in the outer layer of skin) together, resulting in natural cell turnover and a more “compacted” stratum corneum for improved skin smoothness and texture, and smoothed fine lines and wrinkles.
  2. Increases skin thickness
    Increases autocrine growth factor amphiregulin that activates the growth factor receptor on the surface of keratinocytes, causing them to differentiate and proliferate and leading to epidermal thickening and improvements in fine lines and wrinkles.
  3. Improves hydration and immunity
    Boosts the body’s production of hyaluronic acid in the connective tissue between layers of skin, improving hydration and bolstering the immune system.


Dermal benefits:

  1. Suppresses free-radical-induced MMP production
    Inhibits AP-1, the protein that activates the production of skin-degrading matrix metalloproteinase (MMPs), including collagenase (which destroys collagen), to protect and preserve healthy collagen in the skin.
  2. Reduces UV impact on the skin
    Boosts MMP inhibitor TIMP-1 to directly block the production of collagen-destroying MMPs triggered by sun exposure.
  3. Regulates elastin
    Inhibits the overexpression of the elastase enzyme (which is often tripled after UV damage) as well as elafin (which stops the body from removing the excess elastin from the skin) to more effectively regulate elastin production after sun exposure.
  4. Prevents vitamin A deficiency after sun damage
    Reverses the suppression of retinoid receptors after UV exposure, ensuring that the dermis doesn’t suffer any vitamin A deficiency. 
  5. Enhances collagen production
    Increases both the fibroblast (which produces new collagen) number and activity in the dermis, stimulating new collagen production over a period of 10–12 months.


If you have fine lines, wrinkles, thinning skin or any other skin ageing concern and want to boost your current skincare regimen with a safe and effective form of retinoic acid, ask your doctor or therapist about all-new Correctives 3.0 RA Serum today.

Need to boost your RA skin results? See the now even higher concentrate Correctives 5.0 RA Serum.

You might also like the recent post we did on how anti-ageing product Dermaheal reintroduces youthful elements to ageing skin and our roundup of the ultimate age-preventing technologies you should know about.

And see some handy skin-health tips for men here

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